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In some embodiments, the chemotherapy-induced ototoxicity is caused by a platinum based chemotherapeutic agent, a bis-platinate, vincristine, an aminoglycoside antibiotic, a macrolide antibiotic, a diuretic or a salicylate

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3 The role of NAC in bone microenvironment 3.1 NAC promotes the osteogenic differentiation of stem cells in the bone immune microenvironment Among the MSCs sourced from various tissues, bone marrow-derived mesenchymal stem cells (BMSCs) and adipose-derived mesenchymal stem cells (AMSCs) are most widely used in bone tissue engineering (Hoang et al., 2022